The new ich e6(r2) integrated addendum requires sponsors to implement systems to manage quality throughout all stages of the trial process. the system should use a risk-based approach including which of the following? citi

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question - in 1827, john walker, a druggist in a small english town, tipped a splint with sulphur, chlorate of potash, and sulphid of antimony, and rubbed it on sandpaper, and it burst into flame. the druggist had discovered the first friction-chemical match, the kind we use to-day. it is called friction-chemical because it is made by mixing certain chemicals together and rubbing them. although walker's match did not require the bottle of acid, nevertheless it was not a good one. it could be lighted only by hard rubbing, and it sputtered and threw fire in all directions. in a few years, however, phosphorus was substituted on the tip for antimony, and the change worked wonders. the match could now be lighted with very little rubbing, and it was no longer necessary to have sandpaper upon which to rub it. it would ignite when rubbed on any dry surface, and there was no longer any sputtering. this was the phosphorus match, the match with which we are so familiar. according the paragraph what was the benefit of the new phosphorus match? it burst into flame when rubbed on sandpaper. it was made by mixing chemicals. it could be ignited on any dry surface. it threw fire in all directions.

answer - matches required natural chemicals

recent improvements in technology/telecommunication/internet have increased the pace of globalization.

explanation:

recent improvements in technology have enhanced the pace of globalization. it is not difficult to recognize that technology has created the human race one big issue. there are several aspects to technology but they all serve to meet us the further. i can beat and be friends with a fellow, thousands of miles away. technology has also bridged the knowledge gap and has presented for the ready transfer of ideas and values.

answer; longitudinal;