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Mathematics, 15.10.2020 08:01, garrettbridges6435
In the early part of this century, the drug company, Merck, produced a powerful non- steroidal anti-inflammatory drug (NSAID) known as Vioxx. Vioxx was very effective in reducing pain due to arthritis and, unlike some NSAIDs, did not cause digestive system or liver problems. However, a couple of years after Vioxx was introduced to the market, some independent studies showed a possible connection between NSAIDs and increased risk of heart attack in the elderly. Since many arthritis sufferers (and many Vioxx users) are elderly, these studies were a cause of concern.
To test whether this was the case for Vioxx, Merck conducted a large-scale study in which 3025 randomly selected elderly Vioxx users were put on the drug while 2875 were given a placebo. The volunteers were monitored for 18 months. During this time, 334 of the Vioxx group members and 272 members of the placebo group suffered heart attacks.
Required:
a. Compute by hand a 90% confidence interval for the difference in heart attack risk between Vioxx users and non-Vioxx users (the placebo group.)
b. Interpret the interval. What action does it suggest should be taken regarding Vioxx?
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In the early part of this century, the drug company, Merck, produced a powerful non- steroidal anti-...
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