The economy of the middle colonies differed from the economy of Virginia described in the excerpt in that the middle colonies more often

In the midwest because it has more moderate climate than the north or south west which makes farming far easier.

The way this small state - large state compromise guards against tyranny is that small states and large states have one note: i am sorry but i was not able to give you the full answer. but i got this answer from

The constant presence of diseases or infectious agents within a given geographic area or population group. it may also refer to the usual prevalence of a given disease with such area or group. it includes holoendemic and hyperendemic diseases. a holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). a hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. so probably family history.