What is a public health issue?
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an issue that is widely reported in the national news
an issue that negatively affects a large part of the population
an issue that has negatively affected people throughout history
an issue that affects some parts of the population more than others

an issue that negatively affects a large part of the population

Explanation:

A public health issue would be an issue that negatively affects a large part of the population.

From the alternatives given, this appears to be the most reasonable definition of a public health issue.

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The answer is the second option: an issue that negatively affects a large part of the population.

Explanation:

I'm going to give you some examples of public health issues:

Among others...

So this is the reason why is your second option as you can see, these three issues above really affect a large part of the population and although they sometimes are reported in the news, they not necessarily need to be reported in order to be considered a public health issue. Also, the other two options are quite lacking, as the third one refers to the past mainly, and diminishes the present; and the last one, well, not quite, it doesn't neccessarily need to affect other areas and others not, it's widely and largely.

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explanation: