Engineering, 03.09.2020 01:01, savrosed

As discussed, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration E of 2.00 HM (.e. 2.00 x 106 moln) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT. The dissociation constant of the complex ED, formed by HIV-RT and the drug D is 1.00 nM (G. e. 1.00 x 109). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i. e. 1.00 x 107)1. Compute the total concentration of [D1] that is needed to bind 90% of the HIV-RT at the given concentration [E] total. 2. Compute the total concentration of [D1] that is needed to bind 99% of the HIV-RT at the given concentration [E] total.3. Compute the total concentration of [D2] that is needed to bind 90% of the HIV-RT at the given concentration [E] total. 4. Compute the total concentration of [D2] that is needed to bind 99% of the HIV-RT at the given concentration [E] total.

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As discussed, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV vi...