Arrange the events for the hydrolysis of amide bonds by chymotrypsin in their correct order.
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Arrange the events for the hydrolysis of amide bonds by chymotrypsin in their correct order.
a. attack by ser 195 to give a tetrahedral intermediate
b. protonation by his 57 and release of the free c-terminus of the hydrolyzed bond
c. protonation by his 57 and release of the free n-terminus of the hydrolyzed bond
d. attack by water, leading to formation of a tetrahedral intermediate
e. binding of substrate to properly position the scissile bond for cleavage
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Answers: 1
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