Initiation of dna replication occurs at an "origin of replication" site that typically includes an at-rich region. initiation benefits from these at-rich regions because

the framers of the constitution insisted that federal judges be nominated instead of elected due to their desire to have judges above the shifting whims of the masses.

the hope, whether achieved or not, was that federal judges would only be beholden to the law and that by not having judges be elected, they would be protected if that law dictated an outcome that ran counter to popular opinion.