What binds to the prokaryotic chromosome to start dna replication?

DNA Helicase

Explanation:

The process of DNA replication is very complex and requires a variety of proteins in the form of Enzymes.

The DNA replication starts at the site which is about 245 base pairs long and is rich in AT sequences called Origin of replication. The origin of replication recognised by an enzyme called DNA helicase which breaks the hydrogen bonds present between the bases and unwinds the DNA. The RNA primase enzymes then synthesizes an RNA primer which gets attached and to which DNA polymerase binds and add nucleotides.

Thus, the first enzyme that binds to the DNA is DNA helicase.

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