If a state law allows the use of medical marijuana but federal law prohibits it, the state law violates which clause of the constitution?

If a state law allows the use of medical marijuana but federal law prohibits it, the state law violates: The supremacy clause of the Constitution
The supremacy clause indicates that in an event where a Federal law and a state law contradict one another, the federal law must be held at a higher standard than the state law

It depends on what you believe, if you’re christian that you would have been told that the first humans were created by god and that we’re all decedent's from adam and eve but scientist say otherwise