Which statement summarizes the central idea of the article? The Louisiana Purchase greatly changed the United States geographically and economically.
The Louisiana Purchase had very little impact on the culture and politics of the United States.
The Louisiana Purchase opened up trade along the Mississippi River for the first time in US history.
The Louisiana Purchase strengthened ties between the United States and both France and Spain.

A

Explanation:

The Louisiana Purchase greatly changed the United States geographically and economically.

an informal structure in a bureaucracy would be something like so-called "office politics". where there's a formal structure set up for the organization, but then an informal subculture as well that has a way of organizing the bureaucracy further. this can be positive because it sets up an added degree of organization, albeit informal, within the bureaucracy.

answer; delirium is a common adverse reaction seen when elderly patients take diphenhydramine;