A mutation occurs when a base in the DNA sequence is replaced by a different base

Ongoing civil wars western roman empire finally collapsed476 c.e. romulus, the last of theroman  emperors in  the west, was overthrown by the germanic leader odoacer, who became the first barbarian to rule in rome. the order that the  roman empire  had brought towestern  europe for 1000 years was no more.

Hamlet's fourth soliloquy is probably his most famous one - "to be or not to be."it is rather different from his previous soliloquies because now he is contemplating something that didn't come up before - suicide. he is thinking whether it is worth it to fight to find his father's murderer when in the end all of them are going to die, so why not die sooner than later. he is contemplating if he should go on fighting or just kill himself and end it all, which is why this soliloquy in particular is rather depressing, hesitant, and gives a deeper insight into hamlet's madness.