What were two major issues faced by the delegates at the opening of the Constitutional Convention of 1787?

Slavery Though the word "slavery" does not appear in the Constitution, the issue was central to the debates over commerce and representation. The "Three-Fifths Compromise" provided that three-fifths (60%) of enslaved people in each state would count toward congressional representation, increasing the number of Southern seats.Though the word "slavery" does not appear in the Constitution, the issue was central to the debates over commerce and representation. The "Three-Fifths Compromise" provided that three-fifths (60%) of enslaved people in each state would count toward congressional representation, increasing the number of Southern seats.In return, Southern states agreed to stop importing slaves from Africa by 1808. As a result, Congress assumed the power to regulate the commercial aspects of slavery.RepresentationLarge and small states fought over representation in Congress. Large states favored representation by population, while small states argued for equal representation by State.Large and small states fought over representation in Congress. Large states favored representation by population, while small states argued for equal representation by State.The "Great Compromise" allowed for both by establishing the House of Representatives, which was apportioned by populations, and the Senate which represented the states equally.

Hope it helps you!