When andrew jackson famously remarked, "john marshall has made his decision. now let him enforce it," he was referring to

 The correct answer is :  He was referring to the inability of the court to enforce its decisions outside the court.

Explanation:  The state of Georgia had jurisdictional problems with the Cherokee that ended with the decision of the Supreme Court, where Judge John Marshall, a court representative, said that Georgia could not impose its laws on the Cherokee, that was when Jackson pronounced those sentences and took advantage the crisis in Georgia to make a deal with the Cherokee chiefs to move.

the anti federalists was a movement that was opposed to the creation of a us federal government. although they were not as organized as the federalists, they also had a large group of leaders, especially in state politics.

the statement "now, in a large extended country, it is impossible to have a representation, possessing the sentiments, and of integrity, to declare the minds of the people” represents the concerns of the anti federalists.

they strongly believed that the federalists were representing the interests of aristocratic elements of society at the expense of the majority of ordinary people, who lived in a rural society.

their fear for the creation of a strong federal government and the president’s power of veto in their opinion would create a tyrannical rule that would dominate the people. they defended the importance of restraining the government’s power towards people at any cost.