Who were the three primary art masters of the 16th century?

The three primary art masters of the 16th century were: michelangelo, raphael, leonardo da vinci.

All three of them possess different range of talent that bring their name to fame within the 16th century. Michael Angelo was a renown painter and sculpture while raphael and leonardo da vinci were known for their ability as a painter and as architects. They often hired by people from the government to works on public infrastructures.