Medicine, 18.03.2021 01:20, INEEDHELP6845

Phenytoin is an anti-epileptic drug. It is a weak acid with a pKa of 8.1 The unionised form is insoluble, and will form a precipitate. Consequently when infusing intravenousy IV) is important
to avoid this from happening.
A pharmacist prepares a phenytoin solution for IV infusion; commonly the pH of infusion solutions is
pH 5.0 A colleague suggests they should consider changing the pH of the solution to avoid
precipitation.
Using the Henderson-Hasselbalch equation, determine 2 onssible pH range which could be used, also
bearing in mind any risks to the patient.

Answers: 3

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Phenytoin is an anti-epileptic drug. It is a weak acid with a pKa of 8.1 The unionised form is inso...