Prior to the introduction of a vaccine, what was the leading cause of bacterial meningitis in children younger than 5 years of age

Explain the pathophysiologic changes that can cause the signs and symptoms associated with common bile duct obstruction.

What is crystallographic data processing and structure determination? what are the physical infrastructures of x-ray crystallographic structural biology? who can tell me detailed information? any would be appreciated. in advance!

Name the bone/structure/process that fits the following description: a) a bone with a complex shape. b) found in the medullary cavity. c) a large, rough process. d) it is thin, like a plate. e) shaft of a long bone. f) a mature bone cell. g) a large, round, smooth process. h) it covers outer surface of bone. i) a shallow depression on surface of bone. j) a roughly cube-shaped bone. k) the covering of epiphysis. l) a very narrow ridge of bone. m) space between lamellae for an osteocyte. n) chamber within diaphysis o) also called wormian bone. p) it secretes new matrix. q) end of a long bone. r) a small, round hole. s) a matrix, arrangement in spongy bone. t) it is a chamber within a bone. u) a network allowing osteocytes to receive nutrients. v) one example is the patella. w) it houses artery, vein and nerve. x) almost flat, smooth surface of a bone. y) a narrow, pointed process.