Why are genomes important to the development of vaccines

Vaccines are the most efficacious means of minimizing the impact of infectious diseases on the human population. The challenges and importance of making vaccines that will meet FDA approval have never been greater. Genomics has the potential to improve the process of vaccine development substantially. Genome sequencing can help to identify genetic patterns related to the virulence of a disease, as well as genetic factors that contribute to immunity or successful vaccine response. All this information could lead to vaccines with better and more specific targets that elicit more successful protective immune responses. Comparing the genome sequences of viruses that cause infection with those that do not may provide additional insights. In turn, genome manipulation can facilitate derivation of attenuated strains or other vehicles for delivery of the desired antigens to stimulate immune response. On the other end of the spectrum, analysis of host diversity can reveal effective immune responses and possibly the genetic basis for inappropriate response. The recent progress in definition of the innate immune system, necessary for acquired response, should facilitate the definition of this host diversity.

Exome sequencing provides a cost-effective alternative to whole genome sequencing, as it targets only the protein coding region of the human genome responsible for a majority of known disease-related variants. Whether you are conducting studies in rare mendelian disorders, complex disease, cancer research, or human population studies, Novogene’s comprehensive human whole exome sequencing (hWES) service provides a high-quality, affordable, and convenient solution.

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