Which process is the major reason behind this? A 54-year-old man has a squamous cell carcinoma of the right lung. Analysis of his germline DNA shows two alleles, m and n, at the microsatellite locus Z tightly linked to the p53 gene. Similar analysis of the neoplastic cells shows the presence of the m allele only. A. Germline mosaicisrnB. Loss of heterozygosityC. P53 Gene amplificationD. Pericentric inversion involving p53 and locus ZE. Point Mutation of allele n

Mrs. h, age 42 years, is experiencing severe rheumatoid arthritis in her wrists, fingers, and knees. the joints are quite inflamed, red, and swollen. she is sitting rigidly in a chair and refuses to put on a sweater, even though she is shivering, or let anyone touch her arms. she has been prescribed an analgesic and an anti-inflammatory drug, but her dose is not due for another hour. she is feeling nauseated, so she has not eaten for the past 8 hours. based on patient history and the signs and symptoms, discuss how the effects of pain are exacerbating her condition.