Explain why a person with nephrotic syndrome develops edema.

Nephrotic syndrome is a group of signs and symptoms due to kidney damage.  

It is characteristic:

-Proteinuria (>3,5 g per 1,73m2 body surface area per day)

-Hypoalbuminemia (<2,5 g/dl)

-Hyperlipidemia

-Edema (the first signs can be seen in the face)

The edema is caused due to the hypoalbuminemia. When oncotic pressure drops, fluid tends to accumulate in interstitial tissues, leaving intravascular space. In response to the dropped volume in intravascular space, the kidneys tends to retain water and sodium, this also contribute to edema developing.  

activation of phospholipase c (plc) indirectly increases intracellular ions through inositol triphosphate (ip3).

answer:

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