A40-year-old male with a symmetrically enlarged thyroid gland associated with elevated levels of t3 and t4 is treated with pth. what is the principal mechanism of action of ptu?
a. iodide transport into the cell
b. release of t4 and t3 to the blood
c. inhibition of thyroidal peroxidase
d. inhibition of proteolysis of thyroglobulin
e. inhibition of iodination and coupling of thyroglobulin

The correct answer is option e. Inhibition of iodination and coupling of thyroglobulin.

Explanation:

PTU or Propylthiouracil is a drug that binds with thyroidal peroxidase and inhibits the iodination or conversion of iodide to iodine so it can not be coupled or incorporate with tyrosines found in thyroglobulin. Normally thyroglobulin degraded to produces T3 and T4 hormones. So, PTU blocks the production of new  T3 and T4 hormones.

Thus, the correct answer is option e. Inhibition of iodination and coupling of thyroglobulin.

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