What territory was the site of numerous spanish missions but was severely depopulated in the 17th century by infectious disease and warfare with other indian tribe?

The Mocama province

The Mocama Province was faced by a number of challenges that led to a sharp decline in its population. It was first plagued by a an infectious disease.In addition, there were series of war between the Spanish colonialists and the English crown forces in the North. Remnant refugees from the province were resettled at st. Augustine.