What main issue did the federalists and anti-federalists disagree?

The Federalists made up of people like Benjamin Franklin and Antifederalists made of people like John Hancock had opposing views about how government should be run. Federalists believed in the Constitution and the Antifederalists preferred the Articles of Confederation. Federalists were for the Bill of Rights where as the Antifederalists weren't. Federalists base was more centred in the urban areas whereas the Antifederalists was more concentrated in the rural areas.

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Explanation:

to protect the united states' role as a world leader, president truman wanted to prevent the soviet union from spreading communism beyond its post-world war ii boundaries. he declared that the united states must assist any nations struggling to prevent a communist takeover.