Why did anti-federalists oppose the constitution?
a. because it provided for separation of powers
b. because it did not have a bill of rights
c. because it favored large states
d. because it could not be amended

The main reason why the Anti-federalists opposed the Constitution is because "it did not have a bill of rights", which they thought meant that the federal government would eventually stomp on the rights of states and citizens. 

More than 4 million enslaved hunan beings in the south and they touched every aspect of the regions social, political and economic life.