What effect did the spanish settlement have on the native americans?

After certain Spanish adventurers, for example, Christopher Columbus started finding new parcels, for example, the Americas, Spanish pilgrims started to touch base in the local region. Be that as it may, as these pilgrims came in the locals were compelled to change a considerable lot of their conventions, customs, and altogether their religion and culture. Likewise, the local tribes needed to manage sharp decays to their populaces because of lethal maladies the Spanish conveyed to them that they were not yet resistant to. 
Alongside sicknesses, Christopher Columbus conveyed something different new to the locals; servitude.

Gun but i don’t know for sure