Can someone help me with this one. Is it ABC or D

Persons or group opposing or hostile to another person or group the definition word is

Which of these events was a severe setback for the u. s. war effort in the pacific?

How does the supremacy clause of the u. s. constitution affect the states? o a. it requires each state to establish a supreme court. b. it declares that the federal government can take away state powers if necessary. o c. it allows state governments to overthrow the federal government if necessary. o d. it ensures that the u. s. constitution overrules each state constitution