Which european powers dominated the great lakes region and mississippi river valley through most of the 18th century?

The French colonies in North America or also called as the New France was the European powers that dominated and extended from the St. Lawrence River all throughout Great Lakes down to Mississippi River valley system.  The New France also had settlers of about 55,000 in peasant society.

 The correct answer is :  French colonies

Explanation:  France explored and claimed an extensive area called New France that included the mouth of the San Lorenzo River, the Great Lakes, the Mississippi River Delta, the Ohio Valley territory. It was the main French colony, which began with the exploration of the San Lorenzo river made by Jacques Cartier.

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1. temperance, abolitionist, suffragist