Based on the information in "edward jenner and the history of smallpox and vaccination,” which sentence best explains how the twentieth century is significant in the historical timeline of smallpox?

it represents an improvement of the vaccination.
it represents a decrease in disease mortality.
it represents a need for revaccination.
it represents the end of the disease.

The answer is: It represents the end of the disease.

Smallpox is a severe contagious disease with temperature and skin eruptions which leave permanent marks. It was completely eradicated through vaccination in 1979. As a consequence, the author of  "Edward Jenner and the History of Smallpox and Vaccination" acclaims Jenner's work and highlights the importance of his discovery in present times.

The answer is: It represents the end of the disease.

Smallpox is a severe contagious disease with temperature and skin eruptions which leave permanent marks. It was completely eradicated through vaccination in 1979. As a consequence, the author of  "Edward Jenner and the History of Smallpox and Vaccination" acclaims Jenner's work and highlights the importance of his discovery in present times.

It represents the end of the disease.

Explanation:

It represents the end of the disease.

Explanation:

the tallest building in the western hemisphere and the sixth tallest building in the world