What significant challenge did cities face as a result of rapid industrialization in the 1800s?

There were many challenges that cities faced as a result of rapid industrialization in the 1800s. With industrialization came the establishment of factories and industries in cities. These led to high levels of pollution and to a reduction in the space that was meant to house residents. Moreover, as people moved to cities to work in these industries, the cities became overpopulated, and the number of poor or unemployed people grew.

president thomas jefferson commissioned the expedition shortly after the louisiana purchase in 1803 to explore and to map the newly acquired territory, to find a practical route across the western half of the continent, and to establish an american presence in this territory before britain and other european powers