Though the acquisitions of land was important why was the control of the Mississippi River even more important? What did it create for our country?

Cherokee  removal, part of the trail of tears, refers to the  forced  relocation between 1836 and 1839 of thecherokee  nation from  their lands ingeorgia, south carolina, north carolina, tennessee, texas, and alabama to the indian territory (present day oklahoma)  in  the thenwestern united states, and the resultant deaths

Ibelieve the answer is 1756.