Read the claim. "The Columbian Exchange harmed indigenous peoples because it brought diseases.”

Which evidence is the most relevant to support this claim?

Historians believe that smallpox killed many indigenous peoples because they had no immunity.
European diseases like smallpox came to indigenous peoples through contact with explorers and settlers.
Between 8 and 115 million indigenous peoples lived in the Americas when Europeans first arrived in the 15th century.
Although European doctors tried to treat diseases, they sometimes harmed indigenous peoples more than they helped.