What effect do you think Spanish settlement had on Native Americans?

Spanish settlement resulted in much suffering and hardship; it turned many Native Americans into slaves and killed millions of them through battle, mistreatment, and disease.

"globalization has greatly impacted the united states and american citizens. first and foremost, globalization has spread american influence throughout the world. globalization has opened up more markets for the united states, which in effect american companies sell their products worldwide. there has been a rise of multinational corporations and their influence has greatly increased."