Once Jerusalem was lost why did that set the Jews as displaced and therefore targets? :

Jerusalem was the place where Jewish people lived freely and in harmony with each other.

Explanation:

When this place was taken over/was lost, the Jews had to seek out places where they can hide and live, causing the Jewish Diaspora at around the time of 597 BC.

According to jewishvirtuallibrary . org,

"The Jewish state comes to an end in 70 AD, when the Romans begin to actively drive Jews from the home they had lived in for over a millennium. But the Jewish Diaspora ("diaspora" ="dispersion, scattering") had begun long before the Romans had even dreamed of Judaea. When the Assyrians conquered Israel in 722, the Hebrew inhabitants were scattered all over the Middle East; these early victims of the dispersion disappeared utterly from the pages of history. However, when Nebuchadnezzar deported the Judaeans in 597 and 586 BC, he allowed them to remain in a unified community in Babylon. Another group of Judaeans fled to Egypt, where they settled in the Nile delta."

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