What step did China take during the Ming dynasty to isolate itself from the rest of the world?

What important discovery was made by edmond halley and alexis clairaut, using newton's ideas of mathematics and gravity? they created the scientific method to outline how science should be conducted. they were able to find the orbit of a comet and predict the year of its return. they discovered the three newest planets--uranus, neptune, and pluto. they explained why objects appear to have color.