What factors contributed to the Cherokees' hardships?

Due to the poor sanitation of the internment camps, deadly diseases such as whooping cough, measles and dysentery spread among the Cherokee.

Explanation:

worcester v. georgia, legal case in which the u.s. supreme court on march 3, 1832, held (5–1) that the states did not have the right to impose regulations on native american land. andrew jackson refused to enforce the ruling, the decision form the basis for most subsequent indian law in the united states.