In what Mesopotamian region was Uruk located

Iraq

Located in the southern region of Sumer (modern day Warka, Iraq), Uruk was known in the Aramaic language as Erech which, it is believed, gave rise to the modern name for the country of Iraq (though another likely derivation is Al-Iraq, the Arabic name for the region of Babylonia)

Uruk was the first major city in Sumer built in the 5th century BC, and is considered one of the largest Sumerian settlements and most important religious centers in Mesopotamia. It was continuously inhabited from about 5000 BC up to the 5th century AD

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they made rome the dominant power in the mediterranean.