Why did few european nations challenge spain in the 1500s?

Spain is considered to be the most powerful nation due to the effect of colonization and thus the European nations challenge Spain in the year 1500.

Explanation:

In the 1950s, Spain had established many colonies in the New World and this new world includes the countries in the north and south of America.

Spain's motivation for colonizing countries was to spread the act of catholicism that stabilizes the prestige and pride of the nation.

The Spanish economic motive exploited American mines to acquire gold and other natural resources in the colonization.

After the effect of colonization, most of the Europeans and other countries in the world categorized Spain as the most powerful country.

. political or economical policy that isolates a country from participating in international relationships. it has been suggested that the united states participates in isolationism because of its lack of involvement in particular wars or alliances.