One of the main reasons that jamestown settlers struggled to survive was that they
were not used to physical labor.
spent too much time looking for the roanoke colonists
befriended the powhatan people
listened to john smith's faulty advice

Were not used to physical labor

Explanation:

The first settlers of Jamestown were not the best people when it came to surviving in a new, unknown, and tough environment. The people that settled were not used to intense physical labor, were not good at agriculture, lacked hunting skills, and were not the best of fighters in case of danger. All of this resulted in immediate struggle for survival of the Jamestown settlers, and the colony soon failed and all of them either died or started living with the natives, leaving Jamestown behind as a failure.

answer; i do believe that the (14th)fourteenth amendment is the correct answer