A patient with osteoarthritis in the knee suffers from severe pain. The orthopedic tells the patient, along with a breakdown of her articular cartilage, there is a reduction of synovial fluid. Why would a lack of synovial fluid influence and increase the pain?.

Investigator a has biological specimens that are coded and linked to identifiers of the source individuals. investigator a provides the specimens to investigator b but does not provide the individual identifiers. investigator b agrees not to re-identify the source individuals. is investigator b's research using the biospecimens human subjects research according to the definition of human subjects research in the federal regulations?