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[120 total points] (public health) in one of the largest human experiments ever conducted, in 1954 a randomized controlled trial was run to see whether a vaccine developed by a doctor named jonas salk was effective in preventing paralytic polio. a total of 401,974 children (ages 6–9), chosen to be representative of those who might be susceptible to the disease, were randomized to two groups: 200,745 children (the control group c) were injected with a harmless saline solution (a placebo) and the other 201,229 children (the treatment group t) were injected with salk’s vaccine. what was the point of giving saline solution to the children who didn’t get the vaccine? explain briefly.

A41-year-old man comes to the clinic complaining of a chronic cough over the past 4 months, which has now been accompanied by haemoptysis. he denies smoking or any past medical history. on physical examination, his head and neck examination is normal. his lungs have diffuse bilateral rales. cardiac examination is normal. laboratory findings reveal na 142 meq/l, k 4.2 meq/l, cl 110 meq/l, hco3 24 meq/l, bun (blood urea nitrogen) 39 mg/dl, creatinine 2.9 mg/dl. urinalysis reveals microscopic haematuria and 4+ proteinuria. which of the following serologic blood tests would most confirm the suspected diagnosis? - anti-glomerular basement membrane antibodies- anti-mitochondrial antibodies- anti-neutrophilic antibodies- anti-parietal cell antibodies- anti-smooth muscle antibodies

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