Which of the following best describes a ground rule double? A: When 2 batters in a row hit doubles.

B: When a batter hits a double, and makes it to 2nd base before the defense can even get the ball to 2nd base.

C: When a batter hits a ball that lands in fair territory in the outfield, then bounces off the ground, and over the fence.

D: When a batter hits a ground ball that makes it past the infielders, and the batter is able to make it to 2nd base for the double.

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Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for

Which method of administration would result in the highest concentration of the drug in the brain?