How do eGFR and proteinuria differ before and after the administration of spironolactone?

Answered below.

Explanation:

Spironolactone is a diuretic of the potassium-sparing class. It acts to prevent the absorption of too much sodium and thereby preserving the potassium levels in the blood.

It is used in the treatment of disease conditions such as hypokalemia, fluid retention, heart failure, nephrotic syndrome and chronic kidney disease.

In certain kidney conditions where there is protein in urine or proteinuria, spironolactone has been used for therapy.

The long-term use of spironolactone in the treatment of proteinuria shows a decrease in the levels of proteinuria.

The estimated glomerular filtration rate or eGFR decreased after one month of treatment using spironolactone.

Spironolactone has been shown therefore, to be beneficial in the control and management of these conditions.