I need help , I don’t know 2 questions

In a study of a weight loss program, 40 subjects lost a mean of 3.0 lb after 12 months. does the weight loss program have practical significance? a. yes, because the weight loss program worked and the subjects lost a mean of 3.0 lb. b. no, because the mean weight loss of 3.0 lb after one year does not seem to justify the program. c. no, because the sample of 40 subjects was too small to determine if the program was useful. d. yes, because the mean weight loss of 3.0 lb after one year does seems to justify the program.

[120 total points] (public health) in one of the largest human experiments ever conducted, in 1954 a randomized controlled trial was run to see whether a vaccine developed by a doctor named jonas salk was effective in preventing paralytic polio. a total of 401,974 children (ages 6–9), chosen to be representative of those who might be susceptible to the disease, were randomized to two groups: 200,745 children (the control group c) were injected with a harmless saline solution (a placebo) and the other 201,229 children (the treatment group t) were injected with salk’s vaccine. what was the point of giving saline solution to the children who didn’t get the vaccine? explain briefly.

What is one limitation of the myplate guidelines