Indicate whether each statement is true or false. 1. the most significant age-related changes in the skeletal system affect quality and quantity of bone matrix. 2. bone mass is at its highest around the age of 30, and men typically have denser bones than women. 3. compact bone is lost first as lamellae become thinner and weaker. 4. a slow loss of the internal spongy bone begins at about age 40 and increases after age 45.