Acurrent problem in modern medicine is the development of drug resistance mutations. this occurs when a mutation arises in a disease-causing microbe making it resistant to a drug and thus rendering the drug useless in treating a specific disease. many useful drugs are competitive inhibitors of specific enzymes, and the drug-resistance mutations prevent the binding of the drug. these types of mutations, in addition to preventing competitive inhibitor binding, can also sometimes reduce the activity of the enzyme. why is that the case?

The reason why drug-resistance mutations reduce certain enzymes activities is due to their inhibition because they cannot give bacterial respond to antibiotics.

Explanation:

In other words, enzymes use a series of specific strategies to overcome the toxic properties of antibiotics that, combined with a resistance agent, completely alter the performance of the drug. In addition, drug-resistance mutations contain fully evaded instruments which complicate the effectiveness of certain antibiotics, for example, penicillin.    

what is the question?

explanation:

if you explain what it is, i'd be happy to you.

low context culture   (lc.):

association:    

relationships begin and end quickly. many people can be inside one's circle; circle's boundary is not clear.

things get done by following procedures and paying attention to the goal.

one's identity is rooted in oneself and one's accomplishments.

social structure is decentralized; responsibility goes further down (is not concentrated at the top).

interaction:

low use of nonverbal elements. message is carried more by words than by nonverbal means.

verbal message is explicit. context is less important than words.

verbal message is direct; one spells things out exactly.

communication is seen as a way of exchanging information, ideas, and opinions.  

disagreement is depersonalized. one withdraws from conflict with another and gets on with the task. focus is on rational solutions, not personal ones. one can be explicit about another's bothersome behavior.

territoriality:

space is compartmentalized and privately owned; privacy is important, so people are farther apart.

temporality:

things are scheduled to be done at particular times, one thing at a time. what is important is that activity is done efficiently.

change is fast. one can make change and see immediate results.

time is a commodity to be spent or saved. one’s time is one’s own.

learning:

reality is fragmented and compartmentalized. one source of information is used to develop knowledge. thinking is inductive, proceeds from specific to general. focus is on detail.

learning occurs by following explicit directions and explanations of others.

an individual orientation is preferred for learning and problem solving.

speed is valued. how efficiently something is learned is important.

hope that                                         : )