In people with sickle-cell disease, red blood cells break down, clump, and clog blood vessels. blood vessels and broken cells accumulate in the spleen. among other symptoms, this leads to physical weakness, heart failure, pain, and brain damage. such a suite of symptoms can be explained by

the pleiotropic effects of the sickle-cell allele

Explanation:

According to my research on the sickle-cell disease, I can say that based on the information provided within the question such a suite of symptoms can be explained by the pleiotropic effects of the sickle-cell allele. This effect occurs when a single gene produces various effects, which can cause the symptoms mentioned in the question.

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