Which of the following is not a possible consequence of a first-time drug use?
a. no notable sensation at all
b. relief from pain or discomfort
c. death from overdose
d. physical and psychological addiction

The option which is not a possible consequence of a first-time drug use is D. physical and psychological addiction. You cannot become addicted to something that you've tried only once - you have to repeat the sensation in order to want it more and more until you've become completely addicted to it. The other options can happen - you can feel no sensation, you often don't feel pain or discomfort anymore, and you can certainly die if you overdose, regardless of whether you've tried drugs only once or 20 times.