What is the conclusion of Among the peaks in Manhattan

.1 shows a Manhattan plot from the first stage of a large-scale GWAS of AD risk loci (Lambert et al., 2013). The plot shows on the y-axis the negative log-base-10 of the P value for each of the polymorphisms in the genome (along the x-axis), when tested for differences in frequency between 17,008 cases and 37,154 controls. The line shows the threshold for genome-wide significance (P < 5 × 10–8). Diamonds represent SNPs with the smallest P values in the overall analysis from that article.

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