What does the metaphor "Fate is the heart of tragedy" mean?

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Which word best describes the author's tone in this excerpt from "that spot" by jack london? i don’t think much of stephen mackaye any more, though i used to swear by him. i know that in those days i loved him more than my own brother. if ever i meet stephen mackaye again, i shall not be responsible for my actions. it passes beyond me that a man with whom i shared food and blanket, and with whom i mushed over the chilcoot trail, should turn out the way he did. i always sized steve up as a square man, a kindly comrade, without an iota of anything vindictive or malicious in his nature. i shall never trust my judgment in men again. why, i nursed that man through typhoid fever; we starved together on the headwaters of the stewart; and he saved my life on the little salmon. and now, after the years we were together, all i can say of stephen mackaye is that he is the meanest man i ever knew. a. excited b. ironic c. indignant d. playful

Who is ¨ the guilty party¨ at the end of the text, and how do his actions contribute to the storys theme?