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Antagonize (v.) 1630s, "to compete with" (obsolete); 1742, "act in opposition to, struggle against continuously,"
from Greek antagonizesthai "to struggle against, oppose, be a rival" from anti "against" (see anti-) + agonizesthai
"to contend for a prize," from agon "a struggle, a contest" (see agony). Meaning "make antagonistic" is by 1882.
When was it first used in English?
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