Plz help Which is the most reasonable hypothesis for the cause of the disorder?

A.
Since extracellular fluid is rich in potassium ions, K+ ions diffuse into the cell readily. Since intracellular fluid is rich in chlorine ions, Cl- ions diffuse out of the cell readily. The mutation causes the cell to be impermeable to Cl-.
B.
Homeostasis requires that the amount of sodium, chlorine, and potassium remain exactly the same at all times. Therefore, energy is needed to move exact quantities of each ion into and out of the cell.
C.
Sodium and potassium must move into and out of the cell to move the charge along the cell membrane. Sodium will readily diffuse into the cell, along the concentration gradient, but to move it back out requires energy in the form of ATP. The mutation causes a malformation in one of the transport proteins, so the process is disrupted.
D.
Sodium and chlorine must move into and out of the cell to move the charge along the cell membrane. Sodium will readily diffuse into the cell, along the concentration gradient, but to move it back out requires energy. The mutation causes a disruption in the shape of ATP and a malformation in one of the transport proteins, so the process is disrupted. Continued production of misshapen ATP and transport proteins would be catastrophic to all body systems.